Rare diseases · Sign or symptom
Atopic dermatitis
HP:0001047
What it means
Atopic dermatitis (AD) or atopic eczema is an itchy, inflammatory skin condition with a predilection for the skin flexures. It is characterized by poorly defined erythema with edema, vesicles, and weeping in the acute stage and skin thickening (lichenification) in the chronic stage.
In infants, atopic dermatitis is known as infantile eczema.
Rare diseases that can present with this20
Common30–79%
6- 13q12.3microdeletion syndrome
- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Early-onset progressive leukoencephalopathy-central nervous system calcification-deafness-visual impairment syndrome
- Idiopathic chronic eosinophilic pneumonia
- Intellectual disability-obesity-prognathism-eye and skin anomalies syndrome
- PGM3-CDG
Sometimes5–29%
11- Alopecia universalis
- Aquagenic palmoplantar keratoderma
- Autosomal dominant Charcot-Marie-Tooth disease type 2Z
- Eosinophilic gastroenteritis
- Generalized pseudohypoaldosteronism type 1
- Hypotrichosis simplex of the scalp
- Immunodeficiency due to selective anti-polysaccharide antibody deficiency
- Keratosis follicularis spinulosa decalvans
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Allergic eczema · Atopic dermatitis, chronic · Atopic eczema · Baby eczema · Dermatitis, Atopic · Infantile eczema · Neurodermatitis · Prurigo Besnier
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.