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Start free with EleplanAquagenic palmoplantar keratoderma
ORPHA:498359Disease
Also called Aquagenic keratoderma · Aquagenic syringeal acrokeratoderma · Aquagenic wrinkling of the palms · Transient reactive papulotranslucent acrokeratoderma
What it is
A rare skin disease characterized by transient wrinkling of the skin, edema, formation of whitish papules, pruritus, burning sensation, or pain, on the palms and/or soles in response to contact with water. Duration of exposure and water temperature affect the rate of development and intensity of the lesions. The condition is more common in females than in males and frequently occurs in patients with cystic fibrosis.
Key facts
- Age of onset
- Adolescent, Adult, Childhood, Infancy
- Inheritance
- Unknown
- Classified as
- Disease
Signs and symptoms
Common30–79%
5These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Gene
ICD-10 codes
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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