Rare diseases · Sign or symptom
Lower limb muscle weakness
Leg weakness
HP:0007340
What it means
Weakness of the muscles of the legs.
Inability to perform rapid, alternating movements.
Rare diseases that can present with this62
Very common80–99%
14- Autosomal dominant Charcot-Marie-Tooth disease type 2E
- Autosomal dominant Charcot-Marie-Tooth disease type 2F
- Autosomal dominant spastic paraplegia type 12
- Autosomal dominant spastic paraplegia type 19
- Autosomal recessive spastic paraplegia type 11
- Autosomal recessive spastic paraplegia type 5A
- Charcot-Marie-Tooth disease type 4B2
- Gerstmann-Straussler-Scheinker syndrome
- GNE myopathy
- Hereditary motor and sensory neuropathy, Okinawa type
- Homocystinuria due to methylene tetrahydrofolate reductase deficiency
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
- Thyrotoxic periodic paralysis
- X-linked Charcot-Marie-Tooth disease type 6
Common30–79%
34- Adult-onset multiple mitochondrial DNA deletion syndrome due to DGUOK deficiency
- Amyotrophic lateral sclerosis
- Autosomal dominant spastic paraplegia type 10
- Autosomal dominant spastic paraplegia type 13
- Autosomal dominant spastic paraplegia type 37
- Autosomal dominant spastic paraplegia type 4
- Autosomal dominant spastic paraplegia type 42
- Autosomal dominant spastic paraplegia type 8
- Autosomal recessive ataxia, Beauce type
- Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect
- Autosomal recessive spastic paraplegia type 21
- Autosomal recessive spastic paraplegia type 28
- Autosomal recessive spastic paraplegia type 48
- Autosomal recessive spastic paraplegia type 55
- Autosomal recessive spastic paraplegia type 76
- Calpain-3-related limb-girdle muscular dystrophy R1
- Combined oxidative phosphorylation defect type 7
- Dysferlin-related limb-girdle muscular dystrophy R2
- Early-onset spastic ataxia-myoclonic epilepsy-neuropathy syndrome
- Fragile X-associated tremor/ataxia syndrome
- Glycogen storage disease due to acid maltase deficiency
- Hemangioblastoma
- IgG4-related pachymeningitis
- Mitochondrial trifunctional protein deficiency
- MYH14-related peripheral neuropathy-myopathy-hoarseness-hearing loss syndrome
- Nelson syndrome
- Neurogenic arthrogryposis multiplex congenita
- Poliomyelitis
- Polyneuropathy associated with IgM monoclonal gammopathy
- Roussy-Lévy syndrome
- Spastic paraplegia type 7
- Superficial siderosis
- Tay-Sachs disease
- X-linked complicated spastic paraplegia type 1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Lower extremity weakness · Lower limb weakness · Muscle weakness in lower limbs
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.