Rare diseases · Sign or symptom
Lower limb hyperreflexia
Overactive lower leg reflex
HP:0002395
What it means
Increased intensity of the a reflex in the leg.
Rare diseases that can present with this39
Always100%
2Very common80–99%
13- Autosomal dominant spastic paraplegia type 10
- Autosomal dominant spastic paraplegia type 29
- Autosomal dominant spastic paraplegia type 3
- Autosomal dominant spastic paraplegia type 6
- Autosomal dominant spastic paraplegia type 9A
- Autosomal recessive spastic paraplegia type 27
- Autosomal recessive spastic paraplegia type 56
- Autosomal recessive spastic paraplegia type 76
- Autosomal recessive spastic paraplegia type 9B
- Autosomal spastic paraplegia type 30
- Autosomal spastic paraplegia type 58
- Kufor-Rakeb syndrome
- Spinocerebellar ataxia type 28
Common30–79%
19- Angelman syndrome due to a point mutation
- Angelman syndrome due to maternal 15q11q13 deletion
- Angelman syndrome due to paternal uniparental disomy of chromosome 15
- Arnold-Chiari malformation type I
- Autosomal dominant dopa-responsive dystonia
- Autosomal dominant spastic paraplegia type 31
- Autosomal recessive dopa-responsive dystonia
- Autosomal recessive spastic paraplegia type 32
- Autosomal recessive spastic paraplegia type 59
- Autosomal recessive spastic paraplegia type 77
- Combined oxidative phosphorylation defect type 7
- Distal deletion 10q syndrome
- Kjellin syndrome
- Kyphoscoliosis-lateral tongue atrophy-hereditary spastic paraplegia syndrome
- Myopathy and diabetes mellitus
- Pyruvate dehydrogenase E2 deficiency
- Spastic paraplegia type 7
- Spinocerebellar ataxia type 18
- X-linked intellectual disability-psychosis-macroorchidism syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Brisk lower extremity reflexes · Hyperreflexia in lower limbs · Hyperreflexia in the lower limbs · Increased deep tendon reflexes in the lower limbs · Leg hyperreflexia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.