Rare diseases · Sign or symptom
Impaired vibration sensation in the lower limbs
Decreased lower limb vibratory sense
HP:0002166
What it means
A decrease in the ability to perceive vibration in the legs.
Rare diseases that can present with this33
Very common80–99%
4Common30–79%
20- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Autosomal dominant spastic paraplegia type 12
- Autosomal dominant spastic paraplegia type 13
- Autosomal dominant spastic paraplegia type 19
- Autosomal dominant spastic paraplegia type 37
- Autosomal dominant spastic paraplegia type 42
- Autosomal dominant spastic paraplegia type 73
- Autosomal dominant spastic paraplegia type 8
- Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect
- Autosomal recessive spastic paraplegia type 32
- Autosomal recessive spastic paraplegia type 60
- Autosomal recessive spastic paraplegia type 66
- Autosomal recessive spinocerebellar ataxia-blindness-deafness syndrome
- Charcot-Marie-Tooth disease type 1E
- KLHL9-related early-onset distal myopathy
- Spastic paraplegia-optic atrophy-neuropathy syndrome
- Spastic paraplegia type 7
- Spinocerebellar ataxia with axonal neuropathy type 1
- X-linked Charcot-Marie-Tooth disease type 6
- X-linked spastic paraplegia type 34
Sometimes5–29%
9- Autosomal dominant dopa-responsive dystonia
- Autosomal dominant spastic ataxia type 1
- Autosomal dominant spastic paraplegia type 38
- Autosomal dominant spastic paraplegia type 9A
- Autosomal recessive axonal neuropathy with neuromyotonia
- Autosomal recessive cerebellar ataxia with late-onset spasticity
- Autosomal spastic paraplegia type 18
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased vibratory sense in lower limbs · Decreased vibratory sense in the lower extremities · Decreased vibratory sense in the lower limbs · Diminished vibratory sensation in the legs · Distal sensory loss, especially vibratory sense · Distal vibratory impairment of the lower limbs
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.