Rare diseases · Sign or symptom
Dysarthria
Difficulty articulating speech
HP:0001260
What it means
Dysarthric speech is a general description referring to a neurological speech disorder characterized by poor articulation. Depending on the involved neurological structures, dysarthria may be further classified as spastic, flaccid, ataxic, hyperkinetic and hypokinetic, or mixed.
Rare diseases that can present with this292
Very common80–99%
51- 17p11.2microduplication syndrome
- 4H leukodystrophy
- Autosomal dominant striatal neurodegeneration
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to RUBCN deficiency
- Autosomal recessive cerebellar ataxia-epilepsy-intellectual disability syndrome due to WWOX deficiency
- Autosomal recessive cerebellar ataxia-psychomotor delay syndrome
- Autosomal recessive cerebelloparenchymal disorder type 3
- Autosomal recessive spastic ataxia-optic atrophy-dysarthria syndrome
- Autosomal recessive spastic paraplegia type 44
- Autosomal recessive spastic paraplegia type 78
- Autosomal spastic paraplegia type 58
- Botulism
- Brain dopamine-serotonin vesicular transport disease
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder
- COASY protein-associated neurodegeneration
- Dystonia-aphonia syndrome
- Episodic ataxia type 7
- Facial onset sensory and motor neuronopathy
- Foodborne botulism
- Fragile X-associated tremor/ataxia syndrome
- Friedreich ataxia
- Infant botulism
- Infantile-onset ascending hereditary spastic paralysis
- Intestinal botulism
- Kennedy disease
- Marinesco-Sjögren syndrome
- MEPAN syndrome
- Mitochondrial membrane protein-associated neurodegeneration
- Neuronal intranuclear inclusion disease
- Noonan syndrome
- Primary dystonia, DYT17 type
- Spastic ataxia with congenital miosis
- Spinocerebellar ataxia type 10
- Spinocerebellar ataxia type 11
- Spinocerebellar ataxia type 20
- Spinocerebellar ataxia type 26
- Spinocerebellar ataxia type 27A
- Spinocerebellar ataxia type 28
- Spinocerebellar ataxia type 29
- Spinocerebellar ataxia type 3
- Spinocerebellar ataxia type 30
- Spinocerebellar ataxia type 31
- Spinocerebellar ataxia type 34
- Spinocerebellar ataxia type 36
- Spinocerebellar ataxia type 38
- Spinocerebellar ataxia type 42
- Urocanic aciduria
- Wilson disease
- Woodhouse-Sakati syndrome
- Wound botulism
Common30–79%
28- 3-methylglutaconic aciduria type 3
- Aceruloplasminemia
- Adult-onset autosomal recessive cerebellar ataxia
- Adult-onset chronic progressive external ophthalmoplegia with mitochondrial myopathy
- Alexander disease
- Alexander disease type II
- Amyotrophic lateral sclerosis
- Ataxia-telangiectasia
- Ataxia-telangiectasia-like disorder
- Ataxia with vitamin E deficiency
- Atypical pantothenate kinase-associated neurodegeneration
- Autosomal recessive ataxia due to PEX10 deficiency
- Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect
- Autosomal recessive cerebellar ataxia due to CWF19L1 deficiency
- Autosomal recessive cerebellar ataxia-movement disorder syndrome
- Autosomal recessive spastic ataxia of Charlevoix-Saguenay
- Autosomal recessive spastic paraplegia type 11
- Autosomal recessive spastic paraplegia type 20
- Autosomal recessive spastic paraplegia type 35
- Autosomal recessive spastic paraplegia type 54
- Autosomal recessive spastic paraplegia type 62
- Autosomal recessive spastic paraplegia type 64
- Autosomal recessive spastic paraplegia type 76
- Autosomal recessive spastic paraplegia type 77
- Autosomal recessive spastic paraplegia type 9B
- CAMOS syndrome
- Cerebellar ataxia, Cayman type
- Cerebellar ataxia with neuropathy and bilateral vestibular areflexia syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dysarthric speech
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.