Rare diseases · Sign or symptom
Tetraparesis
HP:0002273
What it means
Weakness of all four limbs.
Tetraplegia refers to a complete loss of strength, whereas Tetraparesis refers to an incomplete loss of strength.
Rare diseases that can present with this25
Very common80–99%
3Common30–79%
7- Alternating hemiplegia of childhood
- Combined oxidative phosphorylation defect type 27
- Familial infantile bilateral striatal necrosis
- Frontotemporal dementia with motor neuron disease
- Infantile spasms-psychomotor retardation-progressive brain atrophy-basal ganglia disease syndrome
- Pyruvate dehydrogenase E3-binding protein deficiency
- Variegate porphyria
Sometimes5–29%
10- Adult-onset autosomal dominant leukodystrophy
- Autosomal recessive axonal neuropathy with neuromyotonia
- Bickerstaff brainstem encephalitis
- Marchiafava-Bignami disease
- Miller Fisher syndrome
- Overlap myositis
- Primary angiitis of the central nervous system
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Quadriparesis
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.