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Start free with EleplanMultifocal infantile hemangioma with extracutenous involvement
ORPHA:2123Disease
Also called Diffuse neonatal hemangiomatosis · Multifocal infantile haemangioma with extracutenous involvement
What it is
Diffuse neonatal hemangiomatosis is a rare vascular tumor from unknown origin characterized by multiple, progressive, rapidly growing cutaneous hemangiomas (e.g. in the scalp, face, trunk and extremities) associated with widespread visceral hemangiomas in the liver, lungs, gastrointestinal tract, brain, and meninges.
Key facts
- Prevalence
- <1 / 1 000 000
- Age of onset
- Neonatal
- Inheritance
- Not applicable
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Very common80–99%
19- Abnormal cardiovascular system morphology
- Abnormality of coagulation
- Abnormality of metabolism/homeostasis
- Abnormality of the vagina
- Abnormality of the voice
- Abnormal skull morphology
- Anemia
- Ascites
- Hemangiomatosis
- Hepatomegaly
- Hydrops fetalis
- Hypercalcemia
- Patent ductus arteriosus
- Polyhydramnios
- Premature birth
- Renal hypoplasia/aplasia
- Renal insufficiency
- Thrombocytopenia
- Visceral angiomatosis
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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