Rare diseases · Sign or symptom
Reduced left ventricular ejection fraction
HP:0012664
What it means
A diminution of the volumetric fraction of blood pumped out of the ventricle with each cardiac cycle.
The normal range is at least 55 percent.
Rare diseases that can present with this17
Common30–79%
5Sometimes5–29%
10- AApoAIV amyloidosis
- Absence of the pulmonary artery
- Autosomal dominant progressive external ophthalmoplegia
- Congenital aortic valve stenosis
- Dysferlin-related limb-girdle muscular dystrophy R2
- Laminin subunit alpha 2-related congenital muscular dystrophy
- Mucopolysaccharidosis type 3
- T-cell based immunotherapy-associated cytokine release syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 2 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Reduced ejection fraction
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.