Rare diseases · Sign or symptom
Recurrent fever
Episodic fever
HP:0001954
What it means
Periodic (episodic or recurrent) bouts of fever.
Rare diseases that can present with this24
Very common80–99%
7Common30–79%
9- Acute inflammatory demyelinating polyradiculoneuropathy
- Cyclic neutropenia
- Familial hypoaldosteronism
- Hereditary sensory and autonomic neuropathy type 4
- Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
- Leukocyte adhesion deficiency type II
- RIDDLE syndrome
- Severe motor and intellectual disabilities-sensorineural deafness-dystonia syndrome
- X-linked lymphoproliferative disease due to XIAP deficiency
Sometimes5–29%
8- Behçet disease
- Beta-thalassemia major
- Farber disease
- H syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to 9q21.3 microdeletion
- Neurodevelopmental disorder-craniofacial dysmorphism-cardiac defect-skeletal anomalies syndrome due to a point mutation
- Unstable beta globin chain variant disease
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperthermia, episodic · Increased body temperature, episodic · Intermittent fever
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.