Rare diseases · Sign or symptom
Progeroid facial appearance
Premature aged appearance
HP:0005328
What it means
A degree of wrinkling of the facial skin that is more than expected for the age of the individual, leading to a prematurely aged appearance.
Rare diseases that can present with this17
Very common80–99%
9- Atypical Werner syndrome
- Autosomal recessive cutis laxa type 2A
- Autosomal semi-dominant severe lipodystrophic laminopathy
- B4GALT7-related spondylodysplastic Ehlers-Danlos syndrome
- De Barsy syndrome
- Lipodystrophy-intellectual disability-deafness syndrome
- Mandibuloacral dysplasia with type A lipodystrophy
- Progeria-short stature-pigmented nevi syndrome
- Wiedemann-Rautenstrauch syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Aged facial appearance · Prematurely aged face · Prematurely aged facial appearance · Wizened face
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.