Rare diseases · Sign or symptom
Prematurely aged appearance
Precociously senile appearance
HP:0007495
Rare diseases that can present with this26
Very common80–99%
15- Acrogeria
- Ataxia-telangiectasia
- Atypical Werner syndrome
- Campomelia, Cumming type
- Cataract-intellectual disability-hypogonadism syndrome
- Focal facial dermal dysplasia type III
- GAPO syndrome
- Lenz-Majewski hyperostotic dysplasia
- Mandibuloacral dysplasia with type A lipodystrophy
- Microcephalic primordial dwarfism, Montreal type
- Progeria-short stature-pigmented nevi syndrome
- Progeroid syndrome, Petty type
- Seckel syndrome
- Werner syndrome
- Xeroderma pigmentosum-Cockayne syndrome complex
Common30–79%
4The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Prematurely aged appearance
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.