Rare diseases · Sign or symptom
Insulin-resistant diabetes mellitus
Insulin resistant diabetes
HP:0000831
What it means
A type of diabetes mellitus related not to lack of insulin but rather to lack of response to insulin on the part of the target tissues of insulin such as muscle, fat, and liver cells. This type of diabetes is typically associated with increases both in blood glucose concentrations as well as in fasting and postprandial serum insulin levels.
Rare diseases that can present with this18
Very common80–99%
9- Acanthosis nigricans-insulin resistance-muscle cramps-acral enlargement syndrome
- Atypical Werner syndrome
- CIDEC-related familial partial lipodystrophy
- Insulin autoimmune syndrome
- LIPE-related familial partial lipodystrophy
- Microcephalic primordial dwarfism-insulin resistance syndrome
- PPARG-related familial partial lipodystrophy
- Progeria-short stature-pigmented nevi syndrome
- Woodhouse-Sakati syndrome
Common30–79%
8- Acquired generalized lipodystrophy
- AKT2-related familial partial lipodystrophy
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome
- Insulin-resistance syndrome type B
- Mandibuloacral dysplasia
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Rabson-Mendenhall syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Insulin resistant diabetes mellitus · Insulin-resistant diabetes
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.