Rare diseases · Sign or symptom
Increased circulating immunoglobulin concentration
Increased antibody level in blood
HP:0010702
What it means
An increased level of gamma globulin (immunoglobulin) in the blood.
In humans, immunoglobulins comprise the five antibody isotypes IgA, IgD, IgE, IgG and IgM.
Rare diseases that can present with this38
Very common80–99%
7Common30–79%
17- AL amyloidosis
- Autoimmune lymphoproliferative syndrome
- Chilblain lupus
- Congenital analbuminemia
- Cystic echinococcosis
- Cysticercosis
- Encephalitis lethargica
- Erythema elevatum diutinum
- Gaucher disease type 3
- IgG4-related submandibular gland disease
- Japanese encephalitis
- Leishmaniasis
- Mixed connective tissue disease
- PAPA syndrome
- Pneumocystosis
- Pyoderma gangrenosum
- Tularemia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated immunoglobulin levels · Hypergammaglobulinaemia · Hypergammaglobulinemia · Increased circulating antibody concentration · Increased circulating antibody level · Increased gamma globulin · Increased immunoglobulin level · Increased serum gamma globulin
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.