Rare diseases · Sign or symptom
Increased circulating IgE concentration
HP:0003212
What it means
An abnormally increased overall level of immunoglobulin E in blood.
Rare diseases that can present with this26
Very common80–99%
7Common30–79%
9- Eosinophilic granulomatosis with polyangiitis
- Idiopathic chronic eosinophilic pneumonia
- IgG4-related aortitis
- IgG4-related ophthalmic disease
- IgG4-related submandibular gland disease
- Immune dysregulation-polyendocrinopathy-enteropathy-X-linked syndrome
- PGM3-CDG
- T-B-NK- severe combined immunodeficiency due to adenosine deaminase deficiency
- Trichinellosis
Sometimes5–29%
8- Aspergillosis
- Autoimmune lymphoproliferative syndrome
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- Hypotrichosis simplex of the scalp
- IgG4-related kidney disease
- IgG4-related systemic disease
- Skeletal dysplasia-T-cell immunodeficiency-developmental delay syndrome
- T-B+NK+ severe combined immunodeficiency due to IL-7Ralpha deficiency
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated immunoglobulin E · Elevated serum IgE · High immunoglobulin E · Increased circulating IgE level
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.