Rare diseases · Sign or symptom
Impaired mastication
Chewing difficulties
HP:0005216
What it means
An abnormal reduction in the ability to masticate (chew), i.e., in the ability to crush and ground food in preparation for swallowing.
Chewing and swallowing are interrelated. The act of chewing plays a fundamental role in the process of swallowing food. Mastication prepares food for swallowing by breaking it into small particles. Accordingly, loss of teeth has been associated with swallowing difficulties. Chewing difficulties may be caused by loss of teeth, partial dentures, or by tooth pain. Swallowing difficulties, in contrast, are often characterized by difficulties swallowing liquids, reflux, throat spasms, choking on dry food, or dysphagia.
Rare diseases that can present with this23
Very common80–99%
4Common30–79%
6Sometimes5–29%
10- Autosomal recessive spastic paraplegia type 77
- Bilateral generalized polymicrogyria
- Combined oxidative phosphorylation defect type 7
- Congenital fiber-type disproportion myopathy
- Cortical dysgenesis with pontocerebellar hypoplasia due to TUBB3 mutation
- Genetic recurrent myoglobinuria
- Glycogen storage disease due to acid maltase deficiency
- Helsmoortel-Van der Aa syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Chewing difficulty · Difficulty chewing
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.