Rare diseases · Sign or symptom
Hypomimic face
Dull facial expression
HP:0000338
What it means
A reduced degree of motion of the muscles beneath the skin of the face, often associated with reduced facial crease formation.
The movement and position of facial muscles are often interpreted as expressing emotions. Individuals with hypomimic face may be perceived as expressing less emotion than normal.
Rare diseases that can present with this19
Very common80–99%
2Common30–79%
13- Autosomal dominant progressive external ophthalmoplegia
- Birk-Barel syndrome
- Cirrhosis-dystonia-polycythemia-hypermanganesemia syndrome
- Dopa-responsive dystonia due to sepiapterin reductase deficiency
- Dystonia-parkinsonism-hypermanganesemia syndrome
- Glycogen storage disease due to acid maltase deficiency
- Hereditary sensory and autonomic neuropathy due to TECPR2 mutation
- Infantile dystonia-parkinsonism
- Kufor-Rakeb syndrome
- Neuroferritinopathy
- Parkinsonian-pyramidal syndrome
- PLA2G6-related neurodegeneration, adult-onset
- Rapid-onset dystonia-parkinsonism
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased facial expressions · Decreased facial muscle movement · Hypomimia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.