Rare diseases · Sign or symptom
Hyperinsulinemic hypoglycemia
HP:0000825
What it means
An increased concentration of insulin combined with a decreased concentration of glucose in the blood.
Hyperinsulinemic hypoglycemia describes a situation in which the level of insulin is inappropriate for the low level of blood sugar.
Rare diseases that can present with this19
Always100%
3Very common80–99%
9- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Congenital glucokinase-related hyperinsulinism
- Congenital hyperinsulinism due to HNF4A deficiency
- Hyperinsulinism due to HNF1A deficiency
- Hyperinsulinism due to short chain 3-hydroxylacyl-CoA dehydrogenase deficiency
- Hyperinsulinism due to UCP2 deficiency
- Insulinoma
- Non-insulinoma pancreatogenous hypoglycemia syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Hyperinsulinaemic hypoglycaemia · Hyperinsulinemia hypoglycemia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.