Rare diseases · Sign or symptom
Hyperinsulinemia
HP:0000842
What it means
An increased concentration of insulin in the blood.
Rare diseases that can present with this39
Very common80–99%
18- Acquired generalized lipodystrophy
- Atypical Werner syndrome
- Autosomal dominant hyperinsulinism due to Kir6.2 deficiency
- Autosomal dominant hyperinsulinism due to SUR1 deficiency
- Bangstad syndrome
- Congenital hyperinsulinism due to HNF4A deficiency
- Familial partial lipodystrophy, Köbberling type
- Insulinoma
- Insulin-resistance syndrome type B
- Mandibuloacral dysplasia
- Obesity due to congenital leptin deficiency
- Obesity due to leptin receptor gene deficiency
- Obesity due to SIM1 deficiency
- Progressive encephalopathy-severe neurodegeneration-lipodystrophy syndrome
- Retinitis pigmentosa-intellectual disability-deafness-hypogonadism syndrome
- Severe early-onset obesity-insulin resistance syndrome due to SH2B1 deficiency
- Short fifth metacarpals-insulin resistance syndrome
- Woodhouse-Sakati syndrome
Common30–79%
8The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated insulin level
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.