Rare diseases · Sign or symptom
Hypercalcemia
High blood calcium levels
HP:0003072
What it means
The concentration of calcium in the blood circulation is above the upper limit of normal.
Rare diseases that can present with this46
Always100%
3Very common80–99%
5Common30–79%
11- Blue diaper syndrome
- Hereditary pheochromocytoma-paraganglioma
- Hypophosphatasia
- Intellectual disability-seizures-hypophosphatasia-ophthalmic-skeletal anomalies syndrome
- Metaphyseal chondrodysplasia, Jansen type
- Nephropathy-deafness-hyperparathyroidism syndrome
- Non-functioning paraganglioma
- Oculoskeletodental syndrome
- Paternal uniparental disomy of chromosome 1 syndrome
- Sporadic pheochromocytoma/secreting paraganglioma
- VIPoma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Elevated calcium(2+) concentration · Elevated calcium(2+) level · Elevated calcium(2+) level in blood · Hypercalcaemia · Increased calcium in blood · Increased calcium(2+) concentration · Increased calcium(2+) level · Increased calcium(2+) level in blood
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.