Rare diseases · Sign or symptom
Dystrophic toenail
Poor toenail formation
HP:0001810
What it means
Toenail changes apart from changes of the color of the toenail (nail dyschromia) that involve partial or complete disruption of the various keratinous layers of the nail plate.
Rare diseases that can present with this17
Very common80–99%
6Common30–79%
6- Autosomal dominant generalized dystrophic epidermolysis bullosa
- Cleft lip/palate-ectodermal dysplasia syndrome
- Hutchinson-Gilford progeria syndrome
- Localized dystrophic epidermolysis bullosa, acral form
- Localized dystrophic epidermolysis bullosa, nails only
- Transgrediens et progrediens palmoplantar keratoderma
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dystrophic toenail changes · Dystrophic toenails
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.