Rare diseases · Sign or symptom
Decreased total CD4+ T cell proportion
HP:0032218
What it means
Abnormal decrease of helper CD3+CD4+ T cells, measured as percentage of total CD3+ T cells in the blood, compared to a reference range for a given sex and age-group. These are usually measured within the TCR alpha/beta positive population.
Rare diseases that can present with this15
Very common80–99%
4Common30–79%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased helper T cell proportion · Decreased proportion circulating T-helper cells · Decreased proportion of CD4+ cells · Decreased proportion of CD4+ T cells · Decreased proportion of CD4-positive helper T cells · Decreased proportion of CD4-positive T cells · Decreased proportion of CD4-positive, alpha-beta T cells · Reduced helper T cell proportion
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.