Rare diseases · Sign or symptom
Decreased skull ossification
Decreased bone formation of skull
HP:0004331
What it means
A reduction in the magnitude or amount of ossification of the skull.
Rare diseases that can present with this20
Very common80–99%
12- Cloverleaf skull-multiple congenital anomalies syndrome
- Crane-Heise syndrome
- Craniolenticulosutural dysplasia
- Delayed membranous cranial ossification
- Diaphragmatic defect-limb deficiency-skull defect syndrome
- Grant syndrome
- Hajdu-Cheney syndrome
- Osteogenesis imperfecta
- Potocki-Shaffer syndrome
- Progeroid syndrome, Petty type
- Restrictive dermopathy
- Triploidy syndrome
Common30–79%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased calcification of skull · Decreased mineralization of skull · Deficient skull ossification · Hypoossification of skull · Ossification defect of skull · Poorly mineralized skull · Poorly ossified skull · Poorly ossified skull bones
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.