Rare diseases · Sign or symptom
Parkinsonism
HP:0001300
What it means
Characteristic neurologic anomaly resulting from degeneration of dopamine-generating cells in the substantia nigra, a region of the midbrain, characterized clinically by shaking, rigidity, slowness of movement and difficulty with walking and gait.
Rare diseases that can present with this64
Always100%
3Very common80–99%
8Common30–79%
21- Atypical pantothenate kinase-associated neurodegeneration
- Autosomal dominant dopa-responsive dystonia
- Autosomal recessive dopa-responsive dystonia
- Beta-propeller protein-associated neurodegeneration
- Choreoacanthocytosis
- Classic progressive supranuclear palsy syndrome
- Cyanide-induced parkinsonism-dystonia
- Dravet syndrome
- Dystonia 16
- Dystonia-parkinsonism-hypermanganesemia syndrome
- Encephalitis lethargica
- Frontotemporal dementia with motor neuron disease
- Hemiparkinsonism-hemiatrophy syndrome
- Mitochondrial membrane protein-associated neurodegeneration
- Multiple system atrophy
- Multiple system atrophy, parkinsonian type
- Pantothenate kinase-associated neurodegeneration
- PRKAR1B-related neurodegenerative dementia with intermediate filaments
- Rapid-onset dystonia-parkinsonism
- Spinocerebellar ataxia type 12
- Spinocerebellar ataxia type 17
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Parkinsonian disease
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.