Rare diseases · Sign or symptom
Cholelithiasis
Gallstones
HP:0001081
What it means
Hard, pebble-like deposits that form within the gallbladder.
Gallstones range in size from as small as a grain of sand to as large as a golf ball. Cholesterol gallstones are the most common type of gallstone. Gallstones resulting from too much bilirubin in the bile are referred to as pigment stones.
In everyday care
Most people with this sign do not have a rare disease — it appears in common conditions far more often. These general reference pages cover the same topic:
Rare diseases that can present with this34
Common30–79%
6Sometimes5–29%
23- 22q11.2deletion syndrome
- Acromegaly
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome
- Alpha-thalassemia
- Autosomal erythropoietic protoporphyria
- Basel-Vanagaite-Smirin-Yosef syndrome
- Benign recurrent intrahepatic cholestasis
- Beta-thalassemia
and 15 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.