Rare diseases · Sign or symptom
Clumsiness
HP:0002312
What it means
Lack of physical coordination resulting in an abnormal tendency to drop items or bump into objects.
Rare diseases that can present with this64
Very common80–99%
4Common30–79%
31- Ataxia with vitamin E deficiency
- Autosomal recessive axonal Charcot-Marie-Tooth disease due to copper metabolism defect
- Autosomal recessive cerebellar ataxia due to CWF19L1 deficiency
- Childhood-onset autosomal recessive slowly progressive spinocerebellar ataxia
- Childhood-onset nemaline myopathy
- Distal myopathy, Welander type
- Episodic ataxia type 1
- Familial congenital mirror movements
- FRAXE intellectual disability
- Friedreich ataxia
- HNRNPA1-related adult-onset distal myopathy
- Huntington disease
- Infantile-onset autosomal recessive nonprogressive cerebellar ataxia
- Inherited Creutzfeldt-Jakob disease
- Late-infantile/juvenile Krabbe disease
- Leukoencephalopathy-palmoplantar keratoderma syndrome
- Leukoencephalopathy with brain stem and spinal cord involvement-high lactate syndrome
- Machado-Joseph disease type 1
- Machado-Joseph disease type 2
- Machado-Joseph disease type 3
- Metachromatic leukodystrophy, adult form
- Metachromatic leukodystrophy, juvenile form
- Metachromatic leukodystrophy, late infantile form
- Northern epilepsy
- PLA2G6-related neurodegeneration, adult-onset
- Roussy-Lévy syndrome
- Spinal muscular atrophy-progressive myoclonic epilepsy syndrome
- Tay-Sachs disease
- Tremor-ataxia-central hypomyelination syndrome
- X-linked non progressive cerebellar ataxia
- X-linked progressive cerebellar ataxia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.