Rare diseases · Sign or symptom
Involuntary movements
Involuntary muscle contractions
HP:0004305
What it means
Involuntary contractions of muscle leading to involuntary movements of extremities, neck, trunk, or face.
Rare diseases that can present with this46
Very common80–99%
5Common30–79%
25- Aceruloplasminemia
- Atypical juvenile parkinsonism
- Complex regional pain syndrome
- Corticobasal syndrome
- Dentatorubral pallidoluysian atrophy
- Familial or sporadic hemiplegic migraine
- Huntington disease
- Huntington disease-like 1
- Leigh syndrome
- MECP2-related severe neonatal encephalopathy
- Neuroferritinopathy
- NMDA receptor encephalitis
- Paroxysmal exertion-induced dyskinesia
- Paroxysmal non-kinesigenic dyskinesia
- Postencephalitic parkinsonism
- Posterior-predominant lissencephaly-broad flat pons and medulla-midline crossing defects syndrome
- Primary dystonia, DYT2 type
- Progressive supranuclear palsy-corticobasal syndrome
- Proximal myopathy with extrapyramidal signs
- Rasmussen syndrome
- Recurrent metabolic encephalomyopathic crises-rhabdomyolysis-cardiac arrhythmia-intellectual disability syndrome
- Self-limited infantile epilepsy
- Severe X-linked mitochondrial encephalomyopathy
- Sleep-related hypermotor epilepsy
- Spinocerebellar ataxia type 17
Sometimes5–29%
14- African trypanosomiasis
- Bilateral striopallidodentate calcinosis
- Brain-lung-thyroid syndrome
- Combined oxidative phosphorylation defect type 27
- Combined oxidative phosphorylation defect type 39
- Huntington disease-like 2
- Intellectual disability-epilepsy-extrapyramidal syndrome
- Non-specific early-onset epileptic encephalopathy
and 6 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.