Rare diseases · Sign or symptom
Dysesthesia
HP:0012534
What it means
Painful sensations elicited by a nonpainful cutaneous stimulus such as a light touch or gentle stroking over affected areas of the body. Sometimes referred to as hyperpathia or hyperalgesia. Often perceived as an intense burning, dyesthesias may outlast the stimulus by several seconds.
Rare diseases that can present with this26
Very common80–99%
4Common30–79%
8Sometimes5–29%
14- Acute transverse myelitis
- Adrenomyeloneuropathy
- Burning mouth syndrome
- Ependymoma
- Glossopharyngeal neuralgia
- Hyperprolinemia type 2
- Leprosy
- Marburg hemorrhagic fever
and 6 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 1 disease where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dysaesthesia · Dysesthesias · Hyperalgesia · Hyperpathia
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.