Rare diseases · Sign or symptom
Palmoplantar keratoderma
Thickening of palms and soles
HP:0000982
What it means
Abnormal thickening of the skin of the palms of the hands and the soles of the feet.
Rare diseases that can present with this63
Very common80–99%
39- Aquagenic palmoplantar keratoderma
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- Autosomal dominant palmoplantar keratoderma and congenital alopecia
- Autosomal recessive palmoplantar keratoderma and congenital alopecia
- Bazex syndrome
- Cardiofaciocutaneous syndrome
- Corneodermatoosseous syndrome
- Cowden syndrome
- Cutis gyrata-acanthosis nigricans-craniosynostosis syndrome
- Ectodermal dysplasia-skin fragility syndrome
- Focal palmoplantar and gingival keratoderma
- Haim-Munk syndrome
- Huriez syndrome
- Keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome
- Kindler epidermolysis bullosa
- Lamellar ichthyosis
- Leukomelanoderma-infantilism-intellectual disability-hypodontia-hypotrichosis syndrome
- Lipodystrophy due to peptidic growth factors deficiency
- Mal de Meleda
- Microcornea-glaucoma-absent frontal sinuses syndrome
- Mutilating palmoplantar keratoderma with periorificial keratotic plaques
- Naxos disease
- Odonto-onycho dysplasia-alopecia syndrome
- Pachyonychia congenita
- Palmoplantar keratoderma-deafness syndrome
- Palmoplantar keratoderma-esophageal carcinoma syndrome
- Palmoplantar keratoderma, Nagashima type
- Palmoplantar keratoderma-spastic paralysis syndrome
- Palmoplantar keratoderma-XX sex reversal-predisposition to squamous cell carcinoma syndrome
- Papillon-Lefèvre syndrome
- Paraplegia-intellectual disability-hyperkeratosis syndrome
- Pityriasis rubra pilaris
- Progressive symmetric erythrokeratodermia
- Prolidase deficiency
- Punctate palmoplantar keratoderma type 1
- Schöpf-Schulz-Passarge syndrome
- Striate palmoplantar keratoderma
- Superficial epidermolytic ichthyosis
- Tyrosinemia type 2
Common30–79%
15- Acquired ichthyosis
- Ankylosing vertebral hyperostosis with tylosis
- Congenital ichthyosiform erythroderma
- Darier disease
- Focal dermal hypoplasia
- Hidrotic ectodermal dysplasia
- Keratoderma hereditarium mutilans with ichthyosis
- KID syndrome
- Knuckle pads-leukonychia-sensorineural deafness-palmoplantar hyperkeratosis syndrome
- Pili torti-onychodysplasia syndrome
- PLEC-related intermediate epidermolysis bullosa simplex without extracutaneous involvement
- Sézary syndrome
- Thumb deformity-alopecia-pigmentation anomaly syndrome
- Trichodermodysplasia-dental alterations syndrome
- Triple A syndrome
Sometimes5–29%
9- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Autosomal dominant epidermolytic ichthyosis
- Dyskeratosis congenita
- Intermediate generalized junctional epidermolysis bullosa
- Keratosis follicularis spinulosa decalvans
- Mucolipidosis type IV
- Oculodentodigital dysplasia
- Pachydermoperiostosis
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions, and Orphanet separately records 6 diseases where this sign is specifically absent. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Keratoderma · Palmar and plantar keratoderma
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.