Rare diseases · Sign or symptom
Venous insufficiency
Poorly functioning veins
HP:0005293
Rare diseases that can present with this15
Very common80–99%
2Sometimes5–29%
9- Familial multiple nevi flammei
- GJC2-related late-onset primary lymphedema
- Hypermobile Ehlers-Danlos syndrome
- Kaposi sarcoma
- Livedoid vasculopathy
- Microphthalmia with limb anomalies
- Severe hereditary thrombophilia due to congenital protein C deficiency
- Severe hereditary thrombophilia due to congenital protein S deficiency
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Venous insufficiency
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.