Rare diseases · Sign or symptom
Submucous cleft hard palate
HP:0000176
What it means
Hard-palate submucous clefts are characterized by bony defects in the midline of the bony palate that are covered by the mucous membrane of the roof of the mouth. It may be possible to detect a submucous cleft hard palate upon palpation as a notch in the bony palate.
Rare diseases that can present with this27
Very common80–99%
6Common30–79%
9- Blepharophimosis-intellectual disability syndrome, SBBYS type
- Double outlet right ventricle
- Dubowitz syndrome
- Hydrolethalus
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Oculofaciocardiodental syndrome
- Orofaciodigital syndrome type 4
- Osteopathia striata-cranial sclerosis syndrome
- Ventricular extrasystoles with syncopal episodes-perodactyly-Robin sequence syndrome
Sometimes5–29%
10- 1q41q42microdeletion syndrome
- 8q22.1microdeletion syndrome
- Bencze syndrome
- Cardiofaciocutaneous syndrome
- Ear-patella-short stature syndrome
- Hyposmia-nasal and ocular hypoplasia-hypogonadotropic hypogonadism syndrome
- Lenz-Majewski hyperostotic dysplasia
- Myhre syndrome
and 2 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Partial thickness cleft hard palate
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.