Rare diseases · Sign or symptom
Spastic diplegia
HP:0001264
What it means
Spasticity (neuromuscular hypertonia) primarily in the muscles of the legs, hips, and pelvis.
Rare diseases that can present with this19
Common30–79%
8- Childhood-onset spasticity with hyperglycinemia
- Congenital rubella syndrome
- Hydranencephaly
- Juvenile amyotrophic lateral sclerosis
- Late-infantile/juvenile Krabbe disease
- Pyruvate dehydrogenase E3-binding protein deficiency
- Severe oculo-renal-cerebellar syndrome
- X-linked intellectual disability, Golabi-Ito-Hall type
Sometimes5–29%
7The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Spastic diparesis · Spastic diplegic
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.