Rare diseases · Sign or symptom
Sloping forehead
Inclined forehead
HP:0000340
What it means
Inclination of the anterior surface of the forehead from the vertical more than two standard deviations above the mean (objective); or apparently excessive posterior sloping of the forehead in a lateral view.
Measurement requires an angle meter, inclined on the anterior surface of the forehead, in the midline, along a line connecting the hairline to the glabella, compared to the vertical.
Rare diseases that can present with this55
Very common80–99%
16- Amish lethal microcephaly
- Autosomal recessive primary microcephaly
- Bangstad syndrome
- Blepharophimosis-intellectual disability syndrome, SBBYS type
- Bowen-Conradi syndrome
- Cernunnos-XLF deficiency
- Cleidocranial dysplasia
- Distal duplication 15q syndrome
- Intellectual disability, Buenos-Aires type
- MEHMO syndrome
- Microcephaly-cervical spine fusion anomalies syndrome
- Neu-Laxova syndrome
- Nijmegen breakage syndrome
- Ring chromosome 8 syndrome
- Trisomy 18p syndrome
- X-linked intellectual disability, Abidi type
Common30–79%
21- 14q11.2microdeletion syndrome
- 2p15p16.1microdeletion syndrome
- Acrocallosal syndrome
- Acrocraniofacial dysostosis
- Autosomal recessive chorioretinopathy-microcephaly syndrome
- COG4-CDG
- Dubowitz syndrome
- Intellectual disability, Wolff type
- Keutel syndrome
- Lathosterolosis
- Lethal intrauterine growth restriction-cortical malformation-congenital contractures syndrome
- Lissencephaly syndrome, Norman-Roberts type
- Meckel syndrome
- Microcephalic cortical malformations-short stature due to RTTN deficiency
- Microcephalic osteodysplastic primordial dwarfism types I and III
- Orofaciodigital syndrome type 14
- Paraplegia-intellectual disability-hyperkeratosis syndrome
- Pontocerebellar hypoplasia type 2
- Ptosis-upper ocular movement limitation-absence of lacrimal punctum syndrome
- Say-Barber-Miller syndrome
- TARP syndrome
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Posteriorly sloping forehead · Receding forehead
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.