Rare diseases · Sign or symptom
Single transverse palmar crease
HP:0000954
What it means
The distal and proximal transverse palmar creases are merged into a single transverse palmar crease.
The presence of a single palmar crease (instead of the two palmar creases that are typically present).
Rare diseases that can present with this50
Common30–79%
14- 7q11.23microduplication syndrome
- Antenatal multiminicore disease with arthrogryposis multiplex congenita
- CTCF-related neurodevelopmental disorder
- Fallot complex-intellectual disability-growth delay syndrome
- FOXP1 Syndrome
- KBG syndrome
- Maternal uniparental disomy of chromosome 1 syndrome
- Monosomy 22 syndrome
- PLAA-associated neurodevelopmental disorder
- Tetragametic chimerism syndrome
- Tetrasomy 21 syndrome
- Trisomy 8p syndrome
- X-linked microcephaly-growth retardation-prognathism-cryptorchidism syndrome
- Yunis-Varon syndrome
Sometimes5–29%
33- 5q22microdeletion syndrome
- 8q24.3microdeletion syndrome
- 9q33.3q34.11microdeletion syndrome
- Aarskog-Scott syndrome
- Agammaglobulinemia-microcephaly-craniosynostosis-severe dermatitis syndrome
- Basel-Vanagaite-Smirin-Yosef syndrome
- Cerebellar-facial-dental syndrome
- Czeizel-Losonci syndrome
and 25 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Simian crease · Simian creases · Simian line · Single flexion crease · Single palmar crease · Single palmar creases · Single transverse palmar creases · Transverse palmar crease
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.