Rare diseases · Sign or symptom
Simple febrile seizure
HP:0011171
What it means
A short generalized seizure, of a duration of <15 min, not recurring within 24 h, occurring during a febrile episode not caused by an acute disease of the nervous system intracranial infection or severe metabolic disturbance.
Fever may not be detected before the seizure, but it must be present at least in the immediate postacute period. In most cases these seizures are of a generalized tonic-clonic semiology.
Rare diseases that can present with this11
Sometimes5–29%
8- Epilepsy with myoclonic-atonic seizures
- Facial dysmorphism-developmental delay-behavioral abnormalities syndrome due to WAC point mutation
- Hyperlysinemia
- Intellectual disability syndrome due to a DYRK1A point mutation
- Pontocerebellar hypoplasia type 2
- Ring chromosome 21 syndrome
- Self-limited neonatal epilepsy
- Unilateral focal polymicrogyria
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Simple febrile convulsion · Simple febrile seizures · Simple fever fit
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.