Rare diseases · Sign or symptom
Febrile seizure (within the age range of 3 months to 6 years)
Fever induced seizures
HP:0002373
What it means
A febrile seizure is any type of seizure (most often a generalized tonic-clonic seizure) occurring with fever (at least 38 degrees Celsius) but in the absence of central nervous system infection, severe metabolic disturbance or other alternative precipitant in children between the ages of 3 months and 6 years.
Typically febrile seizures are limited to the age range of 3 months to 6 years and not accompanied or preceded by afebrile seizures; in this case febrile seizures are not considered indicative of epilepsy. When febrile seizures occur prior to the age of 3 months, or continue beyond the 6th birthday, or when a person has both febrile seizures and afebrile generalized tonic-clonic seizures then a diagnosis of Febrile Seizures Plus (an epilepsy syndrome) may be made.
Rare diseases that can present with this33
Common30–79%
6- Congenital cerebellar ataxia due to RNU12 mutation
- Dravet syndrome
- DYRK1A-related intellectual disability syndrome
- Genetic epilepsy with febrile seizure plus
- Recessive intellectual disability-motor dysfunction-multiple joint contractures syndrome
- VPS11-related autosomal recessive hypomyelinating leukodystrophy
Sometimes5–29%
22- 19p13.3microduplication syndrome
- Aymé-Gripp syndrome
- Childhood absence epilepsy
- Dihydropyrimidine dehydrogenase deficiency
- DYRK1A-related intellectual disability syndrome due to 21q22.13q22.2 microdeletion
- Early infantile developmental and epileptic encephalopathy
- Early-onset epileptic encephalopathy and intellectual disability due to GRIN2A mutation
- Epilepsy with eyelid myoclonia
and 14 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Febrile convulsion · Febrile seizures · Seizures, febrile, in early childhood · Seizures, generalized, associated with fever
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.