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Start free with EleplanSpinocerebellar ataxia with axonal neuropathy type 2
ORPHA:64753Disease
Also called AOA2 · Ataxia-oculomotor apraxia type 2 · SCAN 2 · SCAR1
What it is
A rare autosomal recessive cerebellar ataxia (ARCA), characterized by progressive cerebellar ataxia associated with frequent oculomotor apraxia, severe neuropathy and an elevated serum alpha-fetoprotein (AFP) level.
Key facts
- Prevalence
- 1-9 / 1 000 000 (France)
- Age of onset
- Adolescent, Adult, Childhood
- Inheritance
- Autosomal recessive
- Classified as
- Disease
Prevalence figures describe populations, not individuals, and are often estimates from a single study. Where the figure is an incidence or a birth prevalence, it says so.
Signs and symptoms
Common30–79%
6Sometimes5–29%
12- Abnormal pyramidal sign
- Babinski sign
- Choreoathetosis
- Dysphagia
- Dystonia
- Elevated circulating creatine kinase concentration
- Head tremor
- Hypercholesterolemia
and 4 more in this range
These ranges are how often a sign appears across everyone diagnosed, not a prediction for one person — most people have some of these and not others. Orphanet also records findings that are specifically absent in this disease; those are in the data but not listed here.
Genes
ICD-10 codes
ICD-10 has no distinct code for most rare diseases, so many are filed under the nearest available one. A shared code identifies the group, not this disease — the ORPHAcode above is what identifies it.
Related health topics
Reached through the ICD-10 categories this disease is filed under, so these describe the broader group rather than this disease specifically.
Cross-references
Orphadata Science: Free access data from Orphanet. © INSERM 1999. Data version 2026-06-23. Available under CC BY 4.0. This is a reference, not medical advice.
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