Rare diseases · Sign or symptom
Retinal pigment epithelial mottling
HP:0007814
What it means
Mottling (spots or blotches of different shades) of the retinal pigment epithelium, i.e., localized or generalized fundus pigment granularity associated with processes at the level of the retinal pigment epithelium.
Rare diseases that can present with this12
Common30–79%
4Sometimes5–29%
5The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Focal hypopigmentation of the retinal pigment epithelium · Retinal pigment epithelium irregularity · RPE irregularity · RPE mottling · Salt and pepper retinal pigmentation · Salt and pepper retinopathy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.