Rare diseases · Sign or symptom

Reduced total natural killer cell count

HP:0040218

What it means

The absolute count of natural killer cells in the blood, per microlitre, is below the lower limit of normal.

Rare diseases that can present with this5

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Reduced natural killer cell number · Reduced NK cell number

Reduced total natural killer cell count

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.