Rare diseases · Sign or symptom
Recurrent infections
Frequent infections
HP:0002719
What it means
Increased susceptibility to infections as manifested by repeated bouts of infection.
Rare diseases that can present with this102
Very common80–99%
23- ALG3-CDG
- Alpha-mannosidosis, infantile form
- Autosomal dominant hyper-IgE syndrome due to STAT3 deficiency
- Autosomal non-syndromic agammaglobulinemia
- Bullous pemphigoid
- Chédiak-Higashi syndrome
- Chronic mucocutaneous candidiasis
- COG7-CDG
- Felty syndrome
- Glycogen storage disease due to glucose-6-phosphatase deficiency
- Lethal ataxia with deafness and optic atrophy
- Leukocyte adhesion deficiency type II
- Netherton syndrome
- Neuronal intestinal pseudoobstruction
- Pemphigus vulgaris
- PGM3-CDG
- Selective IgM deficiency
- Sickle cell anemia
- T-B+NK+ severe combined immunodeficiency due to CD3delta/CD3epsilon/CD3zeta deficiency
- T-B+NK+ severe combined immunodeficiency due to IL-7Ralpha deficiency
- T-cell immunodeficiency with thymic aplasia
- Urocanic aciduria
- Vici syndrome
Common30–79%
45- 15q24microdeletion syndrome
- 21q deletion syndrome
- Adult idiopathic neutropenia
- Alpha-mannosidosis, adult form
- Arthrogryposis-renal dysfunction-cholestasis syndrome
- Babesiosis
- Bloom syndrome
- Bohring-Opitz syndrome
- Chronic graft versus host disease
- Coffin-Siris syndrome
- Congenital atransferrinemia
- Congenital intrinsic factor deficiency
- CTCF-related neurodevelopmental disorder
- Distal deletion 10q syndrome
- Dubowitz syndrome
- Emanuel syndrome
- Familial glucocorticoid deficiency
- Graft versus host disease
- Growth delay-intellectual disability-hepatopathy syndrome
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Intellectual disability-epilepsy-extrapyramidal syndrome
- Kabuki syndrome
- Kleefstra syndrome due to a point mutation
- Maternal uniparental disomy of chromosome 1 syndrome
- Methylmalonic acidemia with homocystinuria type cblF
- Microcephaly-polymicrogyria-corpus callosum agenesis syndrome
- Micrognathia-recurrent infections-behavioral abnormalities-mild intellectual disability syndrome
- Periodontal Ehlers-Danlos syndrome
- Pontocerebellar hypoplasia type 2
- Progressive external ophthalmoplegia-myopathy-emaciation syndrome
- Progressive microcephaly-seizures-cortical blindness-developmental delay syndrome
- Purine nucleoside phosphorylase deficiency
- Pyomyositis
- Qazi-Markouizos syndrome
- Rabson-Mendenhall syndrome
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
- Ring chromosome 14 syndrome
- Rubinstein-Taybi syndrome
- Schimke immuno-osseous dysplasia
- Smith-Lemli-Opitz syndrome
- Sporadic Creutzfeldt-Jakob disease
- STAT1-related autoimmune enteropathy and endocrinopathy-susceptibility to chronic infections syndrome
- Syndromic multisystem autoimmune disease due to Itch deficiency
- Takenouchi-Kosaki syndrome
- X-linked intellectual disability, Wilson type
Sometimes5–29%
11- ALG1-CDG
- Autosomal dominant generalized epidermolysis bullosa simplex, severe form
- DYRK1A-related intellectual disability syndrome
- Gabriele-de Vries syndrome
- Glycogen storage disease due to liver and muscle phosphorylase kinase deficiency
- Glycogen storage disease due to liver phosphorylase kinase deficiency
- Hepatoportal sclerosis
- Hereditary cryohydrocytosis with reduced stomatin
and 3 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Frequent, severe infections · Increased frequency of infection · infections, recurrent · Predisposition to infections · Susceptibility to infection
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.