Rare diseases · Sign or symptom
Recurrent lower respiratory tract infections
Recurrent chest infections
HP:0002783
What it means
An increased susceptibility to lower respiratory tract infections as manifested by a history of recurrent lower respiratory tract infections.
Rare diseases that can present with this12
Common30–79%
5- Autoimmune lymphoproliferative syndrome due to CTLA4 haploinsuffiency
- Idiopathic bronchiectasis
- Laminin subunit alpha 2-related congenital muscular dystrophy
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Recurrent infections associated with rare immunoglobulin isotypes deficiency
Sometimes5–29%
7- CDKL5-deficiency disorder
- Congenital analbuminemia
- Congenital progressive bone marrow failure-B-cell immunodeficiency-skeletal dysplasia syndrome
- CTCF-related neurodevelopmental disorder
- Cystic fibrosis
- Synaptic congenital myasthenic syndrome
- T-B+NK+ severe combined immunodeficiency due to IL-7Ralpha deficiency
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Chronic lung infections · Lower respiratory tract infections
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.