Rare diseases · Sign or symptom
Periorbital hyperpigmentation
Dark circles around the eyes
HP:0001106
What it means
Increased pigmentation of the skin in the region surrounding the orbit of the eye.
Rare diseases that can present with this2
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Dark circles under the eyes · Darkening around the eyes · Idiopathic cutaneous hyperchromia at the orbital region · Infraorbital pigmentation · Periorbital melanosis · Pigmentation around the eyes
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.