Rare diseases · Sign or symptom

Palmoplantar pustulosis

HP:0100847

What it means

A chronic, relapsing, pustular eruption that is localized to the palms and soles.

There are recurrent and painful eruptions of pustules on the palms and the soles of feet that may resolve with red-brown discoloration.

Rare diseases that can present with this3

The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.

Part of the broader category

Also called: Palmoplantar pustules · Pustulosis of palms and soles · Pustulosis palmaris et plantaris

Palmoplantar pustulosis

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This page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.