Rare diseases · Sign or symptom
Pain insensitivity
HP:0007021
What it means
Inability to perceive painful stimuli.
The word Anesthesia is occasionally used to refer to lack of pain sensation, although it is more usually used to denote a medical procedure design to relieve pain.
Rare diseases that can present with this13
Very common80–99%
3Common30–79%
6- Autosomal recessive spastic paraplegia type 28
- Congenital insensitivity to pain with severe intellectual disability
- Hereditary sensory and autonomic neuropathy type 1
- Hereditary sensory and autonomic neuropathy type 5
- Paternal uniparental disomy of chromosome 1 syndrome
- Spinocerebellar ataxia with axonal neuropathy type 1
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Absence of pain sensation
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.