Rare diseases · Sign or symptom
Impaired pain sensation
Decreased pain sensation
HP:0007328
What it means
Reduced ability to perceive painful stimuli.
Rare diseases that can present with this47
Very common80–99%
10- Autosomal dominant Charcot-Marie-Tooth disease type 2F
- Autosomal recessive Charcot-Marie-Tooth disease with hoarseness
- Digital extensor muscle aplasia-polyneuropathy
- Familial dysautonomia
- Gemignani syndrome
- Gómez-López-Hernández syndrome
- Mutilating hereditary sensory neuropathy with spastic paraplegia
- Phelan-McDermid syndrome
- Spastic paraparesis-deafness syndrome
- Xq12-q13.3 duplication syndrome
Common30–79%
18- 13q12.3microdeletion syndrome
- 16p11.2p12.2microdeletion syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2A2
- CDKL5-deficiency disorder
- Charcot-Marie-Tooth disease type 1F
- Charcot-Marie-Tooth disease type 4A
- Flynn-Aird syndrome
- Mowat-Wilson syndrome
- Myalgia-eosinophilia syndrome associated with tryptophan
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Ring chromosome 22 syndrome
- Roussy-Lévy syndrome
- Smith-Magenis syndrome
- Spinocerebellar ataxia type 25
- Stüve-Wiedemann syndrome
- X-linked Charcot-Marie-Tooth disease type 1
- X-linked Charcot-Marie-Tooth disease type 4
- X-linked Charcot-Marie-Tooth disease type 5
Sometimes5–29%
19- Atypical Rett syndrome
- Autosomal dominant Charcot-Marie-Tooth disease type 2W
- Autosomal dominant Charcot-Marie-Tooth disease type 2Y
- Charcot-Marie-Tooth disease type 4C
- Charcot-Marie-Tooth disease type 4G
- Childhood-onset motor and cognitive regression syndrome with extrapyramidal movement disorder
- Distal deletion 12q syndrome
- Down syndrome
and 11 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased pinprick sensation
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.