Rare diseases · Sign or symptom
Orthopnea
HP:0012764
What it means
A sensation of breathlessness in the recumbent position, relieved by sitting or standing.
Rare diseases that can present with this14
Common30–79%
5Sometimes5–29%
9- Absence of the pulmonary artery
- Amyotrophic lateral sclerosis
- Atrial septal defect, ostium secundum type
- Coronary arterial fistula
- Familial isolated restrictive cardiomyopathy
- Fixed subaortic stenosis
- Glycogen storage disease due to acid maltase deficiency
- High altitude pulmonary edema
and 1 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Tracking symptoms like this for someone? Eleplan keeps symptoms, diagnoses, medications and every specialist in one plan.
Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.