Rare diseases · Sign or symptom
Lower limb asymmetry
Left and right leg differ in length or width
HP:0100559
What it means
A difference in length or diameter between the left and right leg.
Rare diseases that can present with this38
Very common80–99%
8- Autosomal recessive hypophosphatemic rickets
- Capillary-lymphatic-venous malformation with segmental distribution
- Cleft lip/palate-deafness-sacral lipoma syndrome
- Dysspondyloenchondromatosis
- Isolated proximal femoral focal deficiency
- Proteus-like syndrome
- Proteus syndrome
- Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome
Common30–79%
9- Familial avascular necrosis of femoral head
- Focal dermal hypoplasia
- Isolated fibular hemimelia
- Lower limb malformation-hypospadias syndrome
- Melorheostosis
- Silver-Russell syndrome
- Silver-Russell syndrome due to an imprinting defect of 11p15
- Splenogonadal fusion-limb defects-micrognathia syndrome
- X-linked dominant chondrodysplasia punctata
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Leg length discrepancy
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.