Rare diseases · Sign or symptom
Infra-orbital crease
Crease in skin under the eye
HP:0100876
What it means
Skin crease extending from below the inner canthus laterally along the malar process of the maxilla and zygoma.
This feature is often found in the presence of hypoplasia of the malar process of the maxilla or zygoma, but should be coded separately.
Rare diseases that can present with this2
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Groove in skin under the eye · Infraorbital crease · Infraorbital creases · Underorbital skin creases
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.