Rare diseases · Sign or symptom
Hypohidrosis
Decreased ability to sweat
HP:0000966
What it means
Abnormally diminished capacity to sweat.
Rare diseases that can present with this55
Very common80–99%
22- Alopecia-contractures-dwarfism-intellectual disability syndrome
- Amelo-onycho-hypohidrotic syndrome
- Autosomal dominant hypohidrotic ectodermal dysplasia
- Congenital ichthyosiform erythroderma
- Contractures-ectodermal dysplasia-cleft lip/palate syndrome
- Crisponi syndrome
- Dahlberg-Borer-Newcomer syndrome
- Dermotrichic syndrome
- Ectodermal dysplasia-intellectual disability-central nervous system malformation syndrome
- Fabry disease
- Familial dysautonomia
- Hypohidrotic ectodermal dysplasia
- Hypohidrotic ectodermal dysplasia-hypothyroidism-ciliary dyskinesia syndrome
- Hypohidrotic ectodermal dysplasia with immunodeficiency
- Lamellar ichthyosis
- Pallister-Killian syndrome
- Rapid-onset childhood obesity-hypothalamic dysfunction-hypoventilation-autonomic dysregulation syndrome
- Recessive X-linked ichthyosis
- Spinocerebellar ataxia type 34
- Stüve-Wiedemann syndrome
- Syndromic recessive X-linked ichthyosis
- X-linked hypohidrotic ectodermal dysplasia
Common30–79%
17- Absence of fingerprints-congenital milia syndrome
- Amelocerebrohypohidrotic syndrome
- Ankyloblepharon-ectodermal defects-cleft lip/palate syndrome
- Autosomal recessive hypohidrotic ectodermal dysplasia
- CHAND syndrome
- Cockayne syndrome type 1
- Dermoodontodysplasia
- Digital extensor muscle aplasia-polyneuropathy
- Ectodermal dysplasia-skin fragility syndrome
- Focal dermal hypoplasia
- Hypohidrosis-enamel hypoplasia-palmoplantar keratoderma-intellectual disability syndrome
- Ichthyosis follicularis-alopecia-photophobia syndrome
- Leprosy
- Marshall syndrome
- Naegeli-Franceschetti-Jadassohn syndrome
- Phelan-McDermid syndrome
- X-linked lissencephaly with abnormal genitalia
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Also called: Decreased sweating · Impaired sweating · Inadequate sweating · Oligohidrosis · Sweating, decreased
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.