Rare diseases · Sign or symptom
Hyperactive deep tendon reflexes
HP:0006801
Rare diseases that can present with this29
Very common80–99%
2Common30–79%
11- Adult Krabbe disease
- Dysmorphism-short stature-deafness-difference of sex development syndrome
- Hemiparkinsonism-hemiatrophy syndrome
- Isolated succinate-CoQ reductase deficiency
- Madras motor neuron disease
- Mitochondrial membrane protein-associated neurodegeneration
- Mohr-Tranebjaerg syndrome
- Paroxysmal exertion-induced dyskinesia
- Trisomy 8p syndrome
- X-linked intellectual disability-limb spasticity-retinal dystrophy-arginine vasopressin deficiency
- X-linked parkinsonism-spasticity syndrome
Sometimes5–29%
15- Ataxia-telangiectasia-like disorder
- Atypical progressive supranuclear palsy syndrome
- Autosomal recessive cerebellar ataxia due to STUB1 deficiency
- Bilateral frontal polymicrogyria
- DNM1L-related encephalopathy due to mitochondrial and peroxisomal fission defect
- Huntington disease-like 1
- Mucopolysaccharidosis type 3
- Postencephalitic parkinsonism
and 7 more in this range
The range is how often this sign appears among people diagnosed with each disease — it is not a probability of having any of them. Many of these signs also occur in common, non-rare conditions. A sign on this page is a conversation to have with a clinician, not a conclusion.
Part of the broader category
Hyperactive deep tendon reflexes
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Start free with EleplanThis page uses the Human Phenotype Ontology (2026-06-23) — Human Phenotype Ontology Consortium, hpo.jax.org. Disease associations from Orphanet (INSERM), CC BY 4.0. Content is educational and is not medical advice.